Solgate – a biotech start-up based mostly in Klosterneuburg, Austria – is accelerating the event of recent therapies concentrating on solute service (SLC) transporters utilizing automated liquid dealing with methods from INTEGRA Biosciences. This ignored household of membrane proteins mediates the transport of vitamins, metabolites, signalling molecules and ions throughout cell membranes, and it’s linked to a variety of illnesses, together with metabolic circumstances, neuropathologies and immune issues.
Solgate is creating excessive throughput screening assays to find and progress small molecules that may down- or up-regulate SLC operate, and develop these small molecules into drug candidates. The corporate has invested in ASSIST PLUS pipetting robots and VIAFLO digital pipettes to allow speedy, constant and reproducible liquid dealing with throughout a number of initiatives. “Once you’re dealing with lots of of plates throughout a number of pipelines, reproducibility turns into a problem”, defined Georgi Dimchev, Senior Scientist at Solgate. “Handbook pipetting will increase the danger of variability, so we automate as many steps as potential to keep up consistency.”
Automation is especially necessary for experiments repeated weekly. INTEGRA’s methods guarantee constant reagent supply and delicate dealing with of delicate cell layers, serving to the staff protect knowledge high quality and reproducibility.,
The ASSIST PLUS methods and VIAFLO pipettes are precisely what we want. Whether or not you are a start-up or a big lab, these are the sorts of instruments that assist science transfer sooner, and so they have helped us to create a strong screening platform that may develop with the corporate.”
Ivana Rinklake, Analysis Affiliate, Solgate