The life science group Sartorius launches the brand new Octet® R8e biolayer interferometry (BLI) system, offering researchers with its most superior detection capabilities up to now for real-time, high-throughput evaluation of protein-protein, protein-small molecule, and different biomolecular interactions. Increasing the industry-leading fluidic-free Octet® BLI portfolio, the R8e is designed for purposes requiring increased sensitivity, versatile assay design, and longer run instances.
Picture Credit score: Sartorius
Leveraging Sartorius’ proprietary BLI know-how for quick, real-time, and label-free kinetic characterization of binding interactions, the Octet® R8e offers next-level sensitivity for correct knowledge era on the lowest detection limits, increasing analyte vary to low-molecular weight (> 100 Da) and low-abundance (>10 pM) analytes. Compatibility with 96- and 384-well plate codecs provide extra flexibility in assay design, permitting customization to every examine’s distinctive scale, complexity, and value necessities.
Octet® R8e is our most superior BLI system but, designed to future-proof analysis by enhancing the function of BLI in discovery and growth. It delivers the efficiency and reliability that right now’s scientists require to deal with new targets, rising modalities, and more and more complicated packages,”
Nilshad Salim, Product Supervisor of Octet® Methods, Sartorius
“The mix of excessive sensitivity and the flexibility to scale back pattern dimension to 40 μL with our customized 384-well microplates provides researchers most freedom and vital value efficiencies, with out sacrificing knowledge high quality.”
Pattern integrity is a typical problem in BLI assays when long-term kinetic measurements are required to look at sluggish binding interactions or dissociations. A brand new evaporation cowl created for the Octet® R8e system minimizes pattern evaporation from 96-well microplates, sustaining pattern concentrations for as much as 16 hours. This ensures accuracy over prolonged assay durations, permitting for higher knowledge assortment capabilities with out guide intervention.
“The superior evaporation safety is a recreation changer, supported by knowledge exhibiting glorious reproducibility between replicates over 16-hour experiments. It’s equally beneficial for shorter runs, the place minimizing knowledge variations is essential,” provides Salim. “Along with its best-in-class efficiency, the R8e offers scientists with a robust and streamlined different to SPR-based platforms, backed by a model trusted worldwide as the real BLI know-how.”
Octet® BLI techniques have a big world install-base in regulated environments throughout pharma, biotech, and CRO organizations, with profitable use in quite a few investigational new drug purposes. Empowering scientists with high quality knowledge, flexibility, and a user-friendly design, the Octet® R8e system is designed to speed up biopharmaceutical analysis at each stage—from drug discovery to growth, bioprocessing, and high quality management—whereas equipping labs for future purposes.